Effect of mouthrinses w îth SnFj, LaGla, NaF and chlorhexidine on the amount of lipoteichoic acid formed in plaque VIOLET CATHERINE CHARLOTTE BEAZLEY, PER THRANE AND GUNNAR ROLLA

The in vivO' efieet of some cations on the amouBt oflipoteiclioic acid (LTA) formed in plaque was investigated in two studies. In the Oral part five students followed six mouthriosing programs, each of which la.sted 4 d. Rinsing was performed for 1 min eveiy second hour with a test solution (0.05% stannous fluoride (SnFjj; 0.0.5% chlorhexidine gluconale; 0.3%, lanthanum chloride (LaCl,) and 0.05% sodium fluoride iNaF)j, followed 5 min later widi a rinse ofa 15% sucroSiEsolution. Sucrose alone and xylitol rinses were used as controls. The second part involved a group of f 0 students rinsing for 1 week four times daily with a sucrose solution, and for another week lour times daily with the same sucrose solution and in addition, three times daily with a 0.05% SnF^ solution. The individual pfaquesamples were collected after each rinse program, made into a suspension and then divided for protein analysis, carhohydrate analysis and esdmation of LTA by phenol extraction and indii'ect hemagglutination against a specific antjserttm. The total amount of plaque formed and the LTA content were reduced in sucrose plaque hy the chlorhexidine and SnF2 rinse programs, or when xylitol replaced sucrose as the main sugar soorce. There was no significant effeet with LaCl, or NaF. The rinse programs produced changes in the clinical •appearance ofthe plaque.